Migraine Pathophysiology and Treatment

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Migraine: pathophysiology, pharmacology, treatment and future trends.

Migraine treatment has evolved into the scientific arena, but it seems still controversial whether migraine is primarily a vascular or a neurological dysfunction. Irrespective of this controversy, the levels of serotonin (5-hydroxytryptamine; 5-HT), a vasoconstrictor and a central neurotransmitter, seem to decrease during migraine (with associated carotid vasodilatation) whereas an i.v. infusio...

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Migraine diagnosis and pathophysiology.

PURPOSE OF REVIEW This article describes current knowledge regarding headache, especially migraine, and includes information on genetics, anatomy, pathophysiology, and pharmacology in order to demonstrate their relevance to clinical phenomenology. RECENT FINDINGS Animal models show that drugs effective in migraine prevention may work by raising the threshold for initiating cortical spreading ...

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Pathophysiology of migraine.

The cause and pathophysiology of migraine are not well understood. Over the years research into migraine pathophysiology has focused on the physiology and pharmacology of the headache, the changes in cerebral cortex associated with the symptoms of the aura, and more recently the genetics underlying the migraine syndromes. In this discussion, the neuroanatomical structures activated during migra...

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Migraine – Pathophysiology of Pain

Migraine is a primary episodic headache disorder characterized by a cascade of events that involve various combinations of neurologic, gastrointestinal and autonomic changes. Headache is probably caused by activation of meningeal and blood vessel nociceptors combined with an alteration in central pain modulation. Headache and its associated neuro-vascular changes are subserved by the trigeminal...

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[Pathophysiology of migraine chronification].

In approximately 3% of migraineurs, migraine evolves into more protracted and severe conditions annually. Meanwhile, approximately 26% of chronic migraine cases regain the episodic nature of migraine headaches in two years. The prevalence of chronic migraine is estimated to be approximately 1%. Although the pathophysiology of migraine chronification is poorly understood, several studies have de...

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ژورنال

عنوان ژورنال: Pediatric Neurology Briefs

سال: 1999

ISSN: 2166-6482,1043-3155

DOI: 10.15844/pedneurbriefs-13-11-4